Saturday, February 3, 2024

On the Relationship Between All-Cause Mortality and LDL Levels (Data Courtesy of Nature's Scientific Reports -

  I'll break it down for you. The straight horizontal line of 1.0 is the expected death-rate. The bold line represents the hazard-ratio, the death-rate based upon one of the other variables (in this case, LDL cholesterol levels) and the dotted lines are the confidence levels (AKA, margins if error). And as you can see, the farther from the ideal level (which appears to be between 120 to 130) the more room for error.
  Of course the truly concerning part of this graph is that at around 70 all three lines start to significantly exceed the optimal 1.0, and so whatever heart protection that people get from statins and other cholesterol-lowering drugs seems to get negated by an increase in death from other illnesses (cancer, diabetes, various respiratory ailments, etc.). My advice would be that if you're on one of these agents, show your doctor this graph from a reputable journal (i.e., Nature) and have a heart to heart with him (pause for laughter). It just might save your life.
  And for those of you wanting some additional source material, here - European Heart Journal Vol. 39, Issue 40, October 21, 2018 (pages 3641 to 3653) and BMJ Open, published June 2, 2016, 6(6), e010401

No comments: