tag:blogger.com,1999:blog-1327826536005692170.post8072693940294706880..comments2023-08-24T07:27:12.657-07:00Comments on Contra O'Reilly: On the Fact that Most Mutations Tend to Be of a Deleterious Nature Will "take no prisoners" Harthttp://www.blogger.com/profile/02315659209094683602noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-1327826536005692170.post-1755978545969505562015-09-11T15:02:59.196-07:002015-09-11T15:02:59.196-07:00In pondering the good v bad mutation relation to e...In pondering the good v bad mutation relation to evolution, I'm thinking that most<br />mutations are recessive: like Tay-Sachs disease, if two carriers of the recessive<br />gene mate, generally the offspring are not viable long enough to reproduce. There is some evidence, such as generally increased intelligence, that the mutation has<br />postivive/negative effect and since it has been confined to the Ashkenazi Jewish population, genetics studies are relatively focused. However, it's fatal impact on<br />individuals receiving both recessive genes reduces its occurance over time, and likely it disappears over the long run. Conversely, the few mutationswhich offer species improvements may be recessive as well, but the phylogenetic expression not<br />only survives but prospers, thus it becomes widespread and over the long term becomes non-recessive. Evolutionary detail has its complexities, and as you and others note, lack of data, particularly in the far past, requires assumptions which<br />may or may not hold, but newly discovered genetic methods should clarify (if not at<br />first confuse) some of these concepts. For example, recent extensive genetic analysis of recovered ancient DNA from <a href="https://en.wikipedia.org/wiki/Denisovan" rel="nofollow">Denisovan hominims</a> has revealed<br />a niche hominid somewhat between the Neanderthal and concurrent Sapiens in late Pleistocene Europe. The data keeps coming in and various POVs chew on it before<br />it becomes mainstream or obsolete. BB-Idahohttps://www.blogger.com/profile/01388509941702241290noreply@blogger.comtag:blogger.com,1999:blog-1327826536005692170.post-40496265246359490502015-09-10T18:14:38.046-07:002015-09-10T18:14:38.046-07:00
Would you classify WD as a mutation?<br /><br /> Would you classify WD as a mutation?Rusty Shackelfordhttps://www.blogger.com/profile/14232914458379098036noreply@blogger.com